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The Network Manager service is currently enabled by default on Red Hat Enterprise Linux installations where one of these package groups was selected during installation:
Desktop
NM_CONTROLLED will be installed so that your network interface be managed the NetworkManager daemon. This means the traditional means of managing your network interfaces via the /etc/sysconfig/network-scripts/ifcfg-ethX files will no longer work. Thus, our problem.
This only works if mydomain.com is not the domain configured in Postfix. Because Postfix thinks everything is local when you configured it to be local.
To fix this problem modify Postfix main.cf file:
mydestination = localhost.localdomain, localhost
fallback_transport = relay
