This happens when you upgrade the version of Cpanel/WHM.

1. Check the permissions for files as follows:

/usr/local/cpanel/3rdparty/bin/php
/usr/local/cpanel/3rdparty/bin/php-cgi

2. Above files should have 755 permissions. If not then change the permission to 755.

3. Once the permissions are changed, execute the below command from shell

# /scripts/makecpphp

Now you should not receive a phpMyAdmin 500 Internal Server Error.

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